RESEARCH – CBBS Neuronetwork 12: Autophagy mechanisms in stress-induced neuro- and psychopathology

Together with Anke Müller from the Institute of Pharmacology and Toxicology (IPT) at the Otto-von-Guericke University, Elisa Redavide is exploring how neuropeptides associated with stress adaptation may regulate synaptic function via autophagy.

We could show that the anxiolytic neuropeptide Y (NPY) lastingly upregulates autophagy in the cultured cortical and hippocampal neurons, demonstrated by altered levels of the markers LC3II and p62. We are currently investigating how such a regulation affects plasticity-related molecular targets as well as learning and memory.